LEAP-2

This family consists of several mammalian liver-expressed antimicrobial peptide 2 (LEAP-2) sequences. LEAP-2 is a cationic cysteine-rich protein. LEAP-2 contains a core structure with two disulfide bonds formed by cysteine residues in relative 1-3 and 2-4 positions. LEAP-2 is synthesised as a 77-residue precursor, which is predominantly expressed in the liver and highly conserved among mammals. The largest native LEAP-2 form of 40 amino acid residues is generated from the precursor at a putative cleavage site for a furin-like endoprotease. In contrast to smaller LEAP-2 variants, this peptide exhibits dose-dependent antimicrobial activity against selected microbial model organisms [PMID: 12493837].

The below sequences were used to create LEAP-2 sequence signatures:

>CAMPSQ739
MTPFWRGVSLRPIGASCRDDSECITRLCRKRRCSLSVAQE
>CAMPSQ792
MTPFWRGVSLRPVGASCRDNSECITMLCRKNRCFLRTASE

The below sequences were retrieved using LEAP-2 sequence signatures:

> CAMPLEAP, CAMPLEAH | CAMPSQ739 | Q969E1 | 20138667
MTPFWRGVSLRPIGASCRDDSECITRLCRKRRCSLSVAQE
> CAMPLEAP, CAMPLEAH | CAMPSQ1720 | Q95M25 | 20138666
MTPFWRGVSLRPIGASCRDDSECITRLCRKRRCSLSVAQE
> CAMPLEAH | CAMPSQ1721 | Q95JC3 | 20138665
MTPFWRAVSLRPIGASCRDDSECITRLCRKRRCSLSVAQE
> CAMPLEAH | CAMPSQ1722 | Q91X13 | 20138646
MTPFWRGVSLRPIGASCRDDSECITRLCKKRRCSLSVAQE
> CAMPLEAP, CAMPLEAH | CAMPSQ1723 | Q91V13 | 20138644
MTPFWRGVSLRPIGASCRDDSECITRLCRKRRCSLSVAQE
> CAMPLEAH | CAMPSQ1724 | Q95JB4 | 20138457
MTPFWRAVSLRPIGASCRDDSECLTRLCRKRRCSLSVAQE
> CAMPLEAH | CAMPSQ2169 | C7DZ95 | 253560644
LAAWCLVIMVLSQQVASSPVPVMEILSGSVQGVQRSLRRMARMTPLWRIVGTKPHGAYCQ
NNYECSTGICRKGHCSFS
> CAMPLEAH | CAMPSQ2171 | D0Q093 | 238684527
LLAWCLVFLVIVQQVTSSPVPQSDTPLTSVQEVQRSLKRTARMTPLWRIMGTKPHGAYCQ
NHYECSTGICRKGHCSYS
> CAMPLEAH | CAMPSQ2237 | Q64JE5 | 185135465
GVCLVALILMHQVCASPIGSHDSRLSLQQGTKLLERRTRMTPLWRFMGTKPTGAYCRDHF
ECSTQICRRGHCALSGA
> CAMPLEAP, CAMPLEAH | CAMPSQ2250 | Q6QLQ6 | 46487961
RLKRMTPFWRGVSLRPVGASCRDNSECITMLCRKNRCFLRTASE
> CAMPLEAH | CAMPSQ2251 | Q64JE5 | 44921584
SPIGSHDSRLSLQQGTKLLERRTRMTPLWRFMGTKPTGAYCRDHFECSTQICRRGHCALS
GAVHS
> CAMPLEAH | CAMPSQ2253 | Q64KQ7 | 185135449
PEGQRALKRMARMTPLWRTMGTKPYGAYCLNNYECSTGICRGGHCMFSQPIKS
> CAMPLEAH | CAMPSQ2260 | Q2TLX0 | 61394259
LVLMVLAQQVAPSPVREIEAALGSLQGVQRSLRRMARMTPLWRIMGTKPHGAYCQNNYEC
STGICRKGHCSFS
> CAMPLEAH | CAMPSQ2273 | B2LUN1 | 182636874
RRVARMTPLWRIMSSKPFGAYCQNNYECSTGLCRAGHCSTS
> CAMPLEAH | CAMPSQ2306 | B7NZL6 | 284005376
WHLKLFAVLMICLLLLGQVDGSPVPELSSAKRRPRRMTPFWRGVSLRPIGASCRDNAECV
TRLCRKRRCSLSVAQE
> CAMPLEAH | CAMPSQ2351 | H0X0K2 | 395817579
WHLKLCAVLMICLLLLGQVEGSPIPQLSSAKRRLRRMTPFWRGVSLRPIGASCRDDSECI
TRLCRKRRCSLTVAQE
> CAMPLEAH | CAMPSQ2352 | G3WJ22 | 395504386
SQVGSSPLPQQSSTQRRLKRMTPFWRGVSLRPIGASCHDDSECITRLCRKRRCSLNMTQE
> CAMPLEAH | CAMPSQ2353 | H2PGJ2 | 297675968
WHLKLCAVLMIFLLLLGQIDGSPIPEVSSAKRRPRRMTPFWRGVSLRPIGASCRDDSECI
TRLCRKRRCSLSVAQE
> CAMPLEAP, CAMPLEAH | CAMPSQ2354 | B0KWP9 | 296193739
WHLKLCALLMIFLLLLGQINGSPIPEVSSAKRRPQRMTPFWRGVSLRPIGASCRDDSECI
TRLCRKRRCSLSVAQE
> CAMPLEAH | CAMPSQ2355 | H8PHI1 | 307141611
FLTLLCPIQVQTAPVPEDWTGLITRAKRSLLWRWNTLKPVGTSCREHDECGTKYCRKKIC
SFQV
> CAMPLEAH | CAMPSQ2356 | H8PHI2 | 307141613
FLTLLCPIQVQTAPVPEDWTGLITRAKRSLLWRWNTLKPVGASCREHDECGTKYCRKKIC
SFQV
> CAMPLEAH | CAMPSQ2359 | | 354472655
MRKADRCQPIKGNGNCPLSFRLQHLPFAKMLQLKLFAALMTCLLLLSQVNGSPVPELASA
KRSRRMTPFWRGVSLRPIGASCRDDSECITRLCRKRRCSLSVAQE
> CAMPLEAH | CAMPSQ2360 | G5BFF7 | 351705099
WHLKLFAVLMICLLLLGQIDGSPVPALSSSKKRPRRMTPFWRGVSLRPIGASCRDDYECV
SRLCR
> CAMPLEAH | CAMPSQ2361 | | 348557416
QVDGSPVPEKSSVKKRLRRMTPFWRGVSLRPIGASCRDDSECITRLCKKRRCSLSVAQE
> CAMPLEAH | CAMPSQ2362 | | 348540591
VVHAPRRIARMTPLWRIMNSKPFGAYCQNNYECSTGLCRAGHCS
> CAMPLEAH | CAMPSQ2364 | G3U9V1 | 344265995
WPLRLFAVLMTCLLLLGQVDGSPVPELSSAKRRLRRMTPFWRGVSLRPIGASCRDESECI
TRLCRKRRCSLSVAQE
2015, © Biomedical Informatics Centre, NIRRH, Mumbai