This family consists of wide-spectrum antibiotic peptides isolated from the Australian toadlet, Uperoleia mjobergii. Uperins are smaller than most other wide-spectrum antibiotic peptides isolated from amphibians. Uperins adopts a well-defined amphipathic alpha-helix with distinct hydrophilic and hydrophobic faces [PMID: 10461748].

The below sequences were used to create Uperin sequence signatures:

The below sequences were retrieved using Uperin sequence signatures: