This family consists of clavanin proteins from the haemocytes of the invertebrate Styela clava (Sea squirt), a solitary tunicate. The family is made up of four alpha-helical antimicrobial peptides, clavanins A, B, C and D. The tunicate peptides resemble magainins in size, primary sequence and antibacterial activity. Synthetic clavanin A displays comparable antimicrobial activity to magainins and cecropins. The presence of alpha-helical antimicrobial peptides in the haemocytes of a urochordate suggests that such peptides are primeval effectors of innate immunity in the vertebrate lineage [PMID: 9001389].
Sequences retrieved from pattern (1)
CAMPClaP F-x(0,1)-L-x(2,3)-I-[GI]-x(2)-[IV]-x-[GN]-[FI]-[GV]-[HY]-[GL]-[FV]-x-H-[IV]  
  UniProt Name
  P80710 Clavanin-A
  O18493 Clavanin-C
  P80711 Clavanin-B
  P80713 Clavanin-D
  O97395 Clavaspirin
Sequences retrieved from HMM ( 1 )
  GI UniProt Name
  3121854 P80710 Clavanin-A
  3121863 O18493 Clavanin-C
  3121864 P80711 Clavanin-B
  3121865 P80713 Clavanin-D
  67460433 O97395 Clavaspirin

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