Moronecidin

CAMPSQ208

Title :

Moronecidin

GenInfo Identifier :

18034013

Source :

Morone chrysops [White bass]

Taxonomy :

Animalia, Pisces

UniProt:

Q8UUG2

PubMed :

11739390

Length :

Activity :

Antibacterial, Antifungal

Gram Nature :

Gram+ve, Gram-ve

Target :

E.faecalis VRE ( MIC = 5-10 microM), E.faecalis ( MIC = 2.5-5 microM), Listeria monocytogenes ( MIC = 2.5-5 microM), M.luteus ( MIC = 10-20 microM), S.aureus MRSA ( MIC = 1.25-2.5 microM), Staphylococcus epidermitis ( MIC = 5-10 microM), Staphylococcus saprophiticus ( MIC = 5-10 microM), Staphylococcus xylosus ( MIC = >20 microM), Streptococcus agalactiae ( MIC = 1.25-2.5 microM), Streptococcus bovis ( MIC = 1.25-2.5 microM), Streptococcus equisimilis ( MIC = 2.5-5 microM), Streptococcus mitis ( MIC = 1.25-2.5 microM), Streptococcus pneumonae ( MIC = 1.25-2.5 microM), Streptococcous pyrogenes ( MIC = 1.25-2.5 microM), S. iniae KST740 ak ( MIC = 1.25-2.5 microM), S.iniae KSTSi 6P ( MIC = 1.25-2.5 microM), A. hydrophila ( MIC = >20 microM), Burkholderia cepacia ( MIC = >20 microM), Vibrio Cholera ( MIC = 2.5-5 microM), E.coli ( MIC = 5-10 microM), Enterobacter cloacae ( MIC = 10-20 microM), Enterobacter aerogenes ( MIC = 10-20 microM), Klebsiella pneumonae ( MIC = 2.5-5 microM), Klebsiella oxytoca ( MIC = 5-10 microM), Salmonella cholerasuis ( MIC = 10-20 microM), Salmonella typhimurium ( MIC = 10-20 microM), Salmonella arizonae ( MIC = 10-20 microM), S. marcescens ( MIC = >20 microM), S.flexneri ( MIC = 2.5-5 microM), Shigella sonnei ( MIC = 5-10 microM), Yersinia enterocolitica ( MIC = 2.5-5 microM), N.Crassa ( MIC = 1.56-3.12 microM), A.fumigatus ( MIC = 50-100 microM), F.axysporum ( MIC = 0.78-1.56 microM), F.culmorum ( MIC = 0.39-0.78 microM), Candida ablicans ( MIC = 10-20 microM), Candida glabrata ( MIC = 10-20 microM), Candida lusitania ( MIC = 10-20 microM), Candida tropacalis ( MIC = 10-20 microM)

Hemolytic Activity :

Hemolytic activity (10 microM -55HumanRBC, 11 SheepRBC), (20 microM -100HumanRBC, 51Sheep RBC), (40 microM -100HumanRBC, 80Sheep RBC), (80 microM -100HumanRBC, 100SheepRBC)

Validated :

Experimentally Validated

Pfam :

PF08107 : ( Pleurocidin family )

InterPro :

IPR012515 : Antimicrobial12.

AMP Family :

Pleurocidin

Signature :

ID	Type	Pattern / HMM	T. Length
CAMPPleH23	HMM		23

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005576	Cellular Component	Extracellular region	IEA
GO:0042742	Biological Process	Defense response to bacterium	IEA
GO:0050832	Biological Process	Defense response to fungus	IEA
GO:0031640	Biological Process	Killing of cells of other organism	IEA

Sequence:

FFHHIFRGIVHVGRTIHKLVTGG