Pleurocidin

CAMPSQ374

Title :

Pleurocidin

GenInfo Identifier :

38017184

Source :

Pseudopleuronectes americanus [Winter flounder]

Taxonomy :

Animalia, Pisces

NCBI Taxonomy :

8265

UniProt:

P81941, Q90ZY0

PDB:

1Z64

Structure Database :

CAMPST88

PubMed :

9115266 , 10898673 , 12950255 , 12878506

Length :

Activity :

Antibacterial

Gram Nature :

Gram+ve, Gram-ve

Target :

[ Refer PubMed 9115266 :-E.coli ( MIC =2.2?3.3 microM), B.subtilis ( MIC =1.1?2.2 microM), Leucothrix mucor ( MIC =>35.0 microM), S.marcescens ( MIC =>35.0 microM) , P.aeruginosa ( MIC =>35.0 microM), Aeromonas salmonicida ( MIC =17.7?35.0 microM), Cytophaga aquatilis ( MIC =2.2?4.4 microM), Pasteurella haemolytica ( MIC =4.4?8.8 microM), Staphylococcus aureus ( MIC =17.7?35.0 microM), Salmonella typhimurium I ( MIC =8.8?17.7 microM), S. typhimurium II ( MIC =8.8?17.7 microM) ] [ Refer PubMed 10898673 :- E.coli D31( MIC = 3.1 microg/ml), P. aeruginosa 8613-1 ( MIC = 28.0 microg/ml), P. aeruginosa 11122 ( MIC = 62.5 microg/ml) , P. aeruginosa 11173 ( MIC = 37.3 microg/ml) , P. aeruginosa 11291 (MIC = 50.0 microg/ml) , P. aeruginosa 11300 ( MIC = 37.3 microg/ml) , K. pneumoniae 8617 ( MIC = 12.6 microg/ml ) , K. pneumoniae 8660 ( MIC = 15.4 microg/ml ) , K. pneumoniae 8961 ( MIC = 43.8 microg/ml) , S. aureus 8534 ( MIC = 62.5 microg/ml) , S. aureus 8538 ( MIC = 62.5 microg/ml) , S. aureus 8542 ( MIC = 82.9 microg/ml) , S. aureus 8580 ( MIC = 74.7 microg/ml) , C. albicans 8557 ( MIC = 24.8 microg/ml) , C. albicans 8562 ( MIC = 15.4 microg/ml) , C. albicans 11280 ( MIC = 18.7 microg/ml) , C. albicans 11301 ( MIC = 24.8 microg/ml) ] [ Refer PubMed 12950255 :- Aeromonas salmonicida A449 ( MIC = 2microg/ml), 97?4 ( MIC = 2microg/ml)], [Salmonella typhimurium MS7953s supersusceptible ( MIC = 2microg/ml), 14028s parent of MS7953s ( MIC = 16microg/ml)], [Pseudomonas aeruginosa K799 parent of Z61 ( MIC = 8microg/ml), Z61 supersusceptible ( MIC = 4microg/ml)], [Escherichia coli CGSC4908 triple auxotroph ( MIC = 2microg/ml), UB1005 parent of DC2 ( MIC = 4microg/ml)], [Staphylococcus epidermidis Clinical isolate ( MIC = 8microg/ml)], [Staphylococcus aureus Methicillin resistant clinical isolate ( MIC = 8microg/ml)], [Candida albicans Clinical isolate ( MIC = 8microg/ml)] [ Refer PubMed 12878506 :- A. salmonicida 99-1 (MIC = 2 microg/ml), A. salmonicida 97-4 (MIC = 2 microg/ml), S. enterica serovar Typhimurium MS7953s (MIC = 2 microg/ml), S. enterica serovar Typhimurium 14028s (MIC 16 microg/ml), P. aeruginosa K799 (MIC = 8 microg/ml), P. aeruginosa Z61 (MIC = 4 microg/ml), E. coli CGSC 4908 (MIC = 2 microg/ml), E. coli UB1005 (MIC = 4 microg/ml), E. coli DC2 (MIC = 2 microg/ml), S. epidermidis C621 (MIC 8 microg/ml), MRSA C623 (MIC 8 microg/ml), C. albicans C627 (MIC 8 microg/ml) ]

Validated :

Experimentally Validated

Pfam :

PF08107 : ( Pleurocidin family )

InterPro :

IPR012515 : Antimicrobial12.

AMP Family :

Pleurocidin

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005576	Cellular Component	Extracellular region	IEA
GO:0042742	Biological Process	Defense response to bacterium	IEA
GO:0005576	Cellular Component	Extracellular region	IEA
GO:0042742	Biological Process	Defense response to bacterium	IEA

Sequence:

GWGSFFKKAAHVGKHVGKAALTHYL