Neutrophil defensin 4

CAMPSQ396

Title :

GenInfo Identifier :

399352

Source :

Homo sapiens [Human]

Taxonomy :

Animalia, Mammals

NCBI Taxonomy :

9606

UniProt:

P12838

PDB:

1ZMM

Structure Database :

CAMPST95

PubMed :

2500436 , 17088326

Length :

Activity :

Antibacterial, Antifungal

Gram Nature :

Gram+ve, Gram-ve

Target :

[ Refer : 2500436 E. coli (1.2 x l04 colony forming units/ml with an LD50 of 0.085 microg/ml), S. faecalis (3.1 X l04 colony forming units/ml with an LD50 of 2.38 microg/ml), and C. albicans (8 X l03 colony forming units/ml with an LD50 of 0.515 microg/ml) ] [ Refer : 17088326 E. coli ATCC 25922 ( IC99 = 19.0 +/- 4.1 microg/ml) , S. aureus ATCC 29123 ( IC99 >100 microg/ml) , C. albicans ATCC 99788 amphotericin B resistant ( IC90 > 100 microg/ml) ]

Validated :

Experimentally Validated

Pfam :

PF00323 : ( Mammalian defensin )
PF00879 : ( Defensin propeptide )

InterPro :

IPR016327 : Alpha-defensin.
IPR006080 : Defensin_beta/neutrophil.
IPR002366 : Defensin_propep.
IPR006081 : Mammalian_defensins.

AMP Family :

Defensin

Signature :

ID	Type	Pattern / HMM	T. Length
CAMPDefH33	HMM		33

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005576	Cellular Component	Extracellular region	TAS
GO:0005615	Cellular Component	Extracellular space	IEA
GO:0005796	Cellular Component	Golgi lumen	TAS
GO:0042742	Biological Process	Defense response to bacterium	IEA
GO:0050832	Biological Process	Defense response to fungus	IEA
GO:0045087	Biological Process	Innate immune response	TAS
GO:0031640	Biological Process	Killing of cells of other organism	IEA

Sequence:

VCSCRLVFCRRTELRVGNCLIGGVSFTYCCTRV